In this paper, the tip clearance effects on the aeroelastic stability of a last-stage steam turbine model are investigated.Most of the unsteady aerodynamic work contributing to flutter of the long blades of the last-stage of a steam turbine is done near the tip of the blade.The flow in this region is transonic and sensitive to geometric parameters

Abstract Approved antibody-drug conjugates (ADCs) for HER2-positive breast cancer include trastuzumab emtansine and trastuzumab deruxtecan.To develop a differentiated HER2 ADC, we chose an antibody that does not compete with trastuzumab or pertuzumab for binding, conjugated to a reduced potency PBD (pyrrolobenzodiazepine) dimer here payload.PBDs ar

Mining in close distance coal seams (CDCSs) is frequently associated with engineering disasters because of the complicated nature of stress distribution within CDCSs.In order to establish a layout of a roadway to minimize the occurrence of disasters associated with mining CDCS, here the spatial and temporal evolution of stress distribution during t

This paper targets the shale oil reservoirs of middle to high maturity 3 piece horse wall art in four major basins of China, including the Permian Lucaogou Formation of the Jimsar Sag in the Junggar Basin, the Chang 73 Member of the Triassic Yanchang Formation in the Longdong area of the Ordos Basin, the Kong 2 Member of the Paleogene Kongdian Form

Numerous clustering algorithms become invalid when data classes are unbalanced and close to each other, or clusters are arbitrary shapes and have different densities.A novel region density based clustering algorithm, DEDIC, is proposed to meet this challenge.It is based on recognizing dense regions using mutual nearest neighbors and estimating regi